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Selected recent publications


de Kock M, Tarning J, Workman L, Nyunt MM, Adam I, Barnes KI, Denti P. Pharmacokinetics of Sulfadoxine and Pyrimethamine for Intermittent Preventive Treatment of Malaria During Pregnancy and After Delivery. CPT Pharmacometrics Syst Pharmacol. 2017 Jun 9. doi: 10.1002/psp4.12181. [Epub ahead of print]

Hoglund RM, Workman L, …Guerin PJ, White NJ, Barnes KI, Tarning J (2017). Population Pharmacokinetic Properties of Piperaquine in Falciparum Malaria: An Individual Participant Data Meta-Analysis. PLoS Med 10;14(1):e1002212. 

Gutierrez MM, Pillai GC, Felix S, Romero F, Omondi Onyango K, Owusu-Agyei S, Asante KP, Barnes KI, Sinxadi P, Allen E, Abdulla S, Masimirembwa C, Munyoro M, Yimer G, Gebre-Mariam T, Spector J, Ogutu B. Building Capability for Clinical Pharmacology Research in sub-Saharan Africa. Clin Pharmacol Ther 2017 Apr 5. [Epub ahead of print].

Mandimika N, Barnes KI, Chandler CI, Pace C, Allen EN. Working towards consensus on methods used to elicit participant-reported safety data in uncomplicated malaria clinical drug studies: a Delphi technique study. Malar J 2017, 16(1):52.



Denoeud-Ndam L, Dicko A, Baudin E, Guindo O, Grandesso F, Diawara H, Sissoko S, Sanogo K, Traoré S, Keita S, Barry A, de Smet M, Lasry E, Smit M, Wiesner L, Barnes KI, Djimde AA, Guerin PJ, Grais RF, Doumbo OK, Etard JF. Efficacy of artemether-lumefantrine in relation to drug exposure in children with and without severe acute malnutrition: an open comparative intervention study in Mali and Niger. BMC Med 2016 Oct 24;14(1):167.

Silal SP, Little F, Barnes KI, White LJ (2015). Hitting a Moving Target: A Model for Malaria Elimination in the Presence of Population Movement. PLoS One 21; 10(12):e0144990. Erratum in: PLoS One 2016;11(7):e0159784.

Kredo T, Mauff K, … Maartens G, Cohen K, Barnes KI (2016). The interaction between artemether-lumefantrine and lopinavir/ritonavir-based antiretroviral therapy in HIV-1 infected patients. BMC Infect Dis 16:30.

Allen E, Leisegang C, Furtado T, van Loggerenberg F, Lang T. Blended-learning using The Global Health Network online resources: a pilot study. BMJ Global Health 2017, 2(Suppl 20), A54. Poster presented at the Eighth EDCTP Forum, Lusaka, Zambia. November 2016.

Barnes, K, Guérin, P, Hodel, EM, Humphreys G, Pace C, Banda C, Denti P, Allen E, Lalloo D, Mwapasa V, Terlouw A. The IMPACT project: improving the impact of existing malaria products. BMJ Global Health 2017, 2(Suppl 2), A26. Poster presented at the Eighth EDCTP Forum, Lusaka, Zambia. November 2016.

CDISC Therapeutic Area Data Standards: User Guide for Uncomplicated Malaria. V1.0 2017. https://www.cdisc.org/standards/therapeutic-areas/malaria

WWARN Gametocyte Study Group. Gametocyte carriage in uncomplicated Plasmodium falciparum malaria following treatment with artemisinin combination therapy: a systematic review and meta-analysis of individual patient data. BMC Med 2016, 14(1):79.



Silal SP, Little F, Barnes KI, White LJ. Predicting the impact of border control on malaria transmission: a simulated focal screen and treat campaign. Malaria J 2015; 14: 268.

Rosenkranz B, Reid M, Allen E. Medicines development and regulation in Africa. Journal of Medicines Development Sciences. 2015 vol.1(2): 33–36.

Denoeud-Ndam L, Dicko A, Baudin E, Guindo O, Grandesso F, Sagara I, Lasry E, Palma PP, Parra AM, Stepniewska K, Djimde AA, Barnes KI, Doumbo OK, Etard JF. A multi-center, open-label trial to compare the efficacy and pharmacokinetics of Artemether-Lumefantrine in children with severe acute malnutrition versus children without severe acute malnutrition: study protocol for the MAL-NUT study. BMC Infect Dis 2015; 15: 228.

Kerpel-Fronius S, Rosenkranz B, Allen E, Bass R, Demotes Mainard J, Dodoo A, Dubois DJ, Hela M, Kern S, Massud J, Silva H, Whitty J.  Education and training for medicines development, regulation and clinical research in emerging countries. Front. Pharmacol doi: 10.3389/fphar.2015.00

Worldwide Antimalarial Resistance Network (WWARN) AL Dose Impact Study Group. The effect of dose on the antimalarial efficacy of artemether-lumefantrine: a systematic review and pooled analysis of individual patient data. Lancet Infect Dis 2015; 15(6): 692-702.

WorldWide Antimalarial Resistance Network (WWARN) AS-AQ Study Group. The effect of dosing strategies on the therapeutic efficacy of artesunate-amodiaquine for uncomplicated malaria: a meta-analysis of individual patient data. BMC Medicine 2015; 13: 66. (free article)



Allen EN, Gomes M, Yevoo L, Egesah O, Clerk C, Byamugisha J, Mbonye A, Were E, Mehta U, Atuyambe LM. Influences on participant reporting in the World Health Organisation drugs exposure pregnancy registry: a qualitative study. BMC Health Serv Res 2014; Oct 31, 14(1): 525.

White NJ, Ashley EA, Recht J, Delves MJ, Ruecker A, Smithuis FM, Eziefula AC, Bousema T, Drakeley C, Chotivanich K, Imwong M, Pukrittayakamee S, Prachumsri J, Chu C, Andolina C, Bancone G, Hien TT, Mayxay M, Taylor WR, von Seidlein L, Price RN, Barnes KI, Djimdé A, ter Kuile F, Gosling R, Chen I, Dhorda MJ, Stepniewska K, Guérin P, Woodrow CJ, Dondorp AM, Day NP, Nosten FH. Assessment of therapeutic responses to gametocytocidal drugs in Plasmodium falciparum malaria. Malar J 2014 Dec 9; 13: 483.  (Free PMC article)

Silal SP, Little F, Barnes KI, White LJ. Towards malaria elimination in Mpumalanga, South Africa: a population-level mathematical modelling approach. Malar J 2014 Aug 3;13:297.  

Lourens C, Lindegardh N, Barnes KI, Guerin PJ, Sibley CH, White NJ, Tarning J. Benefits of a pharmacology antimalarial reference standard and proficiency testing program provided by the Worldwide Antimalarial Resistance Network (WWARN).  Antimicrob Agents Chemother. 2014; 58(7): 3889-94.  (Free PMC article)

Zaloumis SG, Tarning J, Krishna S, Price RN, White NJ, Davis TM, McCaw JM, Olliaro P, Maude RJ, Kremsner P, Dondorp A, Gomes M, Barnes K, Simpson JA. Population pharmacokinetics of intravenous artesunate: a pooled analysis of individual data from patients with severe malaria. CPT Pharmacometrics Syst Pharmacol 2014 Nov 5; 3:e145.  (Free PMC article)



Allen EN, Chandler CI, Mandimika N, Pace C, Mehta U, Barnes KI. Evaluating harm associated with anti-malarial drugs: a survey of methods used by clinical researchers to elicit, assess and record participant-reported adverse events and related data. Malar J 2013 Sep 16;12:325. doi: 10.1186/1475-2875-12-325.  (Free PMC article)

Allen EN, Chandler CIR,Mandimika N, Barnes KI. Eliciting adverse effects data from participants in clinical trials (protocol). The Cochrane Library 2013; 9.2.

Allen EN, Mushi AK, Massawe IS, Vestergaard LS, Lemnge M, Staedke SG, Mehta U, Barnes KIB, Chandler CIR. How experiences become data: The process of eliciting adverse event, medical history and concomitant medication reports in antimalarial and antiretroviral interaction trials. BMC Med Res Methodol 2013; 13(1): 140. (Free PMC article)

Morris N, Frean J, Baker L, Ukpe IS, Barnes KI, Kruger P, Mabuza A, Raswiswi E, Maharaj R, Blumberg L, Moonasar D. Re-defining the extent of malaria transmission in South Africa: implications for chemoprophylaxis. S Afr Med J 2013 Oct 2;103(11):861-4. doi: 10.7196/samj.7533.

Silal SP, Barnes KI, Kok G, Mabuza A, Little F. Exploring the seasonality of reported treated malaria cases in Mpumalanga, South Africa. PLoS One 2013 Oct 29;8(10):e76640. doi: 10.1371/journal.pone.0076640. eCollection 2013.  (Free PMC article)

Upke IS, Moonasar D, Raman J, Barnes KI, Baker L, Blumberg L. Case management of malaria: treatment and chemoprophylaxis. S Afr Med J 2013 Aug 29;103(10 Pt 2):793-8.

Walubo A, Barnes KI, Kwizera E, Greeff O, Rosenkranz B, Maartens G. Clinical pharmacology becomes a specialty in South Africa. S Afr Med J 2013 Jan 9;103(3):150-1.

WorldWide Antimalarial Resistance Network (WWARN) DP Study Group. The effect of dosing regimens on the antimalarial efficacy of dihydroartemisinin-piperaquine: a pooled analysis of individual patient data. PLoS Med 2013 Dec;10(12):e1001564; discussion e1001564. doi: 10.1371/journal.pmed.1001564. Epub 2013 Dec 3. Review. Erratum in: PLoS Med. 2013 Dec;10(12). doi:10.1371/annotation/3db421e4-3e27-4442-8092-2ad1b778f371.  (Free PMC article)